🧑‍⚕️ FREE MSRA PODCAST – Stevens-Johnson Syndrome (SJS): Emergency Recognition & Management🔥 Your essential, high-yield crash course on SJS—perfect for the MSRA and real-life practice. Listen up for life-saving revision!

Key Learning Points

📌 Definition & Spectrum• Stevens-Johnson Syndrome (SJS) is a rare but severe mucocutaneous reaction—most often to medications, sometimes infections• Marked by blistering rash, widespread skin detachment, and mucosal involvement• Part of the SJS-TEN spectrum (differentiated by % body surface area involved)

🚩 Causes & Risk Factors• Drugs: Sulphonamides, anticonvulsants (carbamazepine, lamotrigine), allopurinol, NSAIDs• Infections: Mycoplasma pneumoniae, herpes simplex, influenza (especially in children)• Genetic predisposition (HLA alleles), HIV infection, previous SJS, immunosuppression

🩺 Clinical Features• Prodrome: Fever, malaise, sore throat, then sudden widespread erythematous/purpuric rash• Blistering and epidermal detachment, positive Nikolsky sign• Severe, painful mucosal erosions: mouth, eyes, genitals• Lesions start on trunk, spread to limbs, palms, soles• May rapidly progress to multi-organ involvement

🧠 Mnemonic: SJSS: Stop the drug immediatelyJ: Junctions (mucosal) involvedS: Sloughing of skin

🔬 Diagnosis & Classification• Clinical diagnosis is key—history of new drug exposure or recent infection• Biopsy confirms keratinocyte necrosis (for unclear cases or to rule out differentials)• Classify:

SJS: 30% BSA

⚡ Differential Diagnoses• Toxic epidermal necrolysis (TEN)• Erythema multiforme• Bullous pemphigoid, pemphigus vulgaris• Staphylococcal scalded skin syndrome (SSSS)• Drug-induced rashes

🏥 Investigations• FBC, U&Es, LFTs, CRP/ESR, coagulation, cultures• Skin swabs, serology if infection suspected• SCORTEN score predicts severity/mortality

💊 Management (UK/NICE)• Immediate withdrawal of offending drug—non-negotiable• Admit to ITU/burns unit for specialist supportive care• IV fluids, wound care, analgesia, nutritional and eye support• Monitor for sepsis, multi-organ failure• Steroids/IVIG: Specialist advice only—controversial role

🌟 Prognosis & Complications• Mortality: SJS 5–10%, TEN >30%• Long-term: Skin scarring, pigment changes, strictures, chronic eye disease, blindness• Acute: Sepsis, dehydration, respiratory failure, DIC, multi-organ failure

📎 More MSRA Revision for Stevens-Johnson Syndrome:📝 Revision Notes: https://www.passthemsra.com/topic/stevens-johnson-syndrome-revision-notes/💬 Flashcards: https://www.passthemsra.com/topic/stevens-johnson-syndrome-flashcards/🧠 Accordion Q&A: https://www.passthemsra.com/topic/stevens-johnson-syndrome-accordion-qa-notes/🚀 Rapid Quiz: https://www.passthemsra.com/topic/stevens-johnson-syndrome-rapid-quiz/🧪 Full Quiz: https://www.passthemsra.com/quizzes/stevens-johnson-syndrome/🎓 Dermatology Course: https://www.passthemsra.com/courses/dermatology-for-the-msra/

🌐 For more free & premium revision resources:https://www.passthemsra.com

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Erscheinungs­datum: 16.6.2025, 23:40:59