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All Things Urticaria – Learning about urticaria with Prof. Dr. Torsten Zuberbier

All Things Urticaria – Learning about urticaria with Prof. Dr. Torsten Zuberbier

UCARE, the Global Allergy and Asthma Excellence Network for Urticaria
Veröffentlicht: 2025-03-11
© UCARE, the Global Allergy and Asthma Excellence Network for Urticaria
All Things Urticaria – Learning about urticaria with Prof. Dr. Torsten Zuberbier - QR Code
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104 Folgen
Audio
Anhören auf Apple Podcasts
Gratis0%
104 Folgen
Audio
Anhören auf Apple Podcasts
Veröffentlicht: 2025-03-11
© UCARE, the Global Allergy and Asthma Excellence Network for Urticaria
Aktuelle Folge
Episode 105 – Decoding Urticaria: Mast Cells, Triggers & Immune cell crosstalk

Episode 105 – Decoding Urticaria: Mast Cells, Triggers & Immune cell crosstalk

Länge: 21:47
Abspielen
In this episode, Prof. Torsten Zuberbier (Charité Berlin, GA²LEN) welcomes Dr. Stefan Frischbutter, senior researcher at the Institute of Allergy in Berlin, to explore the fascinating world of mast cells and urticaria. 
They discuss: 🔬 The critical role of mast cells in immune responses and skin conditions like urticaria. 💡 How temperature, autoantibodies, and nerves can trigger mast cell activation. 🦠 Different types of mast cell activation: IgE, IgG autoantibodies & pseudo-allergens. 🧪 New research techniques to study mast cells and identify better treatments. 💊 How eosinophils, neutrophils & T-cells influence chronic urticaria severity. 📢 The latest advances in urticaria treatment and why biopsies could guide therapy. 
Join us for an insightful discussion on the immune system’s “orchestrators” and how scientific discoveries are shaping the future of urticaria treatment! 
Key Learnings from the  epsiode:
Mast cells act as immune response directors, responding to heat, cold, allergens, stress, and autoantibodies. 
Urticaria has multiple causes, including IgE and IgG autoantibodies, pseudo-allergen receptors (MRGPRX2), and nerve signals. 
Not all urticaria cases are histamine-driven—other immune cells like eosinophils and neutrophils play a major role. 
Chronic spontaneous urticaria patients often have autoantibodies targeting mast cells, making treatment challenging. 
Taking a skin biopsy at the right time (after a wheal disappears) can reveal immune cell involvement and guide personalized treatments. 
New research techniques, like mast cell activation tests and ex-vivo skin models, help identify triggers and potential treatments. 
Different immune cells require different treatments, and eosinophil/neutrophil-driven urticaria may need specialized drugs. 
Exciting future treatments are emerging, and ongoing research will provide better-targeted therapies for urticaria patients. 
Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here.
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Folgen-ID: 1000698746017
GUID: dcb596da-7fdd-4901-95b0-0d60b1bf075e
Erscheinungs­datum: 11.3.2025, 15:07:43

Beschreibung

Since 2020 this podcast is an invaluable resource for health care professionals, and anyone interested in learning more about urticaria. In the first 97 episodes, Prof. Marcus Maurer († 31.07.2024) is joined by colleagues for in-depth discussions on the latest research and opinion on the pathogenesis and treatment of urticaria. Prof. Torsten Zuberbier has taken on this role. All opinions expressed are those of the faculty. This content should not be taken as medical advice and is for informational purposes only. Learn more about the network and its activities here: https://ucare-network.com/

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