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Matthew Bartholomew, unorthodox but effective physician to Michaelhouse college in medieval Cambridge, is as worried as anyone about the pestilence that is ravaging Europe and seems to be approaching England. But he is distracted by the sudden and inexplicable death of the Master of Michaelhouse - a death the University authorities do not want investigated.

But Matt is determined to get to the truth, leading him into a tangle of lies and intrigue that cause him to question the innocence of his closest friends - and even his family - just as the Black Death finally arrives...